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Tesi etd-05092006-100608


Thesis type
Tesi di dottorato di ricerca
Author
Servidio, Dora
email address
d.servidio@libero.it
URN
etd-05092006-100608
Title
Treatment of the gingival hyperplasia with metronidazole gel(enza) in heart transplant patients treated with cyclosporine
Settore scientifico disciplinare
ING-IND/34
Corso di studi
BIOMATERIALI
Commissione
relatore Prof. Montebugnoli, Lucio
Parole chiave
  • Metronidazole gel
  • Heart transpant patients
  • Gingival hyperplasia
  • Cyclosporine A
Data inizio appello
04/06/2006;
Consultabilità
completa
Riassunto analitico
The cyclosporine-induced gingival overgrowth(go) is a widely documented side effect. Among the methods used to trat this clinical manifestation, the non surgical periodontal treatment associated with plaque control provided controversial results. Interesting results have been obtained using metronidazole systemically; this drug, however, interferes with the CSA metabolism, thus contra-indicating the simultaneous administration of the two molecules. At present, metronidazole is also available as mucoadhesive gel, wich allows to reach appropriate local concentrations without systemic side effects. Aim of this study is to evaluate the efficacy of locally-delivered metronidazole used in association with the therapy of go in heart transplant patients.
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