• agenti di contrasto
• Photon Counting
• SPCCT

Spectral photon-counting computed tomography (SPCTT) is a recent imaging technique that has significant potential for clinical applications. One of the key advantages of SPCTT is its ability to detect x-ray photons based on their energy, which allows for the simultaneous quantification of multiple contrast agents. In this study, our objective was to explore the contrast capabilities of various elements using a prototype SPCCT scanner modified for clinical purposes.

Our study focused on evaluating the contrast-enhancing properties of Pt(II), Pt(IV), Re(III), Ir(IV), W(II), Au(III), and Gd(III) as potential contrast agents. Among these, Au(III), Gd(III), and W(II) exhibited better attenuation. Furthermore, we investigated the potential of heterogenous mixtures containing reverse micelle loaded with W(II), Au(III), and Gd(III) salts as biological delivery systems. The results of our investigation showed that reverse micelles (PLGA/PEG) loaded with the same tested W(II), Au(III), and Gd (III) salts exhibited similar trends observed for homogeneous metal complexes.

We also conducted in-vitro experiments on U-87 type cells that yielded positive results, although limitd to a feasibility study, indicating the potential of Gd(III), Au(III), and W(II) as contrast agents in SPCCT imaging. These findings highlight the feasibility of developing contrast agents using nanoparticle/nanovescicles systems and demonstrate the promising potential of SPCTT.

In conclusion, our study provides valuable insights into the contrast capabilities of different elements and their potential for use as contrast agents in SPCTT imaging. These findings could aids to pave the way for the development of more effective and efficient contrast agents for clinical imaging applications.