ETD

• amino acids
• cross coupling
• organic chemistry
• Pterostilbene

Synthesis of functionalizable analogues of Resveratrol and Pterostilbene and their conjugation to peptide sequences, like new lead molecules with antimicrobial, antioxidant or antitumor activity. By using of simple and inexpensive methodologies for C-C bond formation, functionalized analogues of Resveratrol and Pterostilbene were prepared and amino acid sequences were subsequently linked on them. In detail, the analogues indicated above were functionalized with amino, hydroxyl and carboxylic groups, functional groups which will allow the peptide sequence to be subsequently inserted through the formation of an ester or peptidic bond. The insertion of the peptide sequence will have two possible functions: conveying and releasing the organic (bioactive) scaffold within the organism or increasing the biological properties of the bioactive molecule thanks to a synergy of molecule action / peptide. To this end, the inserted peptide sequences must be chosen not only on the basis of the role they must have (carrier or biological action) but also on the biological target on which they must act.