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Tesi etd-01232018-105345


Thesis type
Tesi di laurea magistrale
Author
ROCCO, DALILA
URN
etd-01232018-105345
Title
Synthesis and characterization of organo-iron complexes with potential anticancer activity
Struttura
CHIMICA E CHIMICA INDUSTRIALE
Corso di studi
CHIMICA
Supervisors
relatore Prof. Marchetti, Fabio
Parole chiave
  • Metal-based drugs
  • Synthesis
  • Optimization
  • Iron
  • Vinyliminium
  • Anticancer
Data inizio appello
08/02/2018;
Consultabilità
Parziale
Data di rilascio
08/02/2021
Riassunto analitico
The main objectives of the present work of thesis are the following:
1. Optimization of the synthesis of diiron vinyliminium complexes, taking into account their air and water stability;
2. Synthesis of new diiron vinyliminium complexes with variable substituents, to tune electronic and steric factors with the aim of evaluating the effects of these variations on the anticancer activity;
3. Synthesis of new monoiron vinyl-aminocarbene complexes using an optimized procedure, and preliminary evaluation of their cytotoxicity.
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