Tesi etd-09242009-105354 |
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Tipo di tesi
Tesi di laurea specialistica
Autore
PISCITELLI, RACHELE
URN
etd-09242009-105354
Titolo
Aspetti fisiopatologici di RhoA/Rho-kinase:modulazione farmacologica e prospettive terapeutiche
Dipartimento
FARMACIA
Corso di studi
FARMACIA
Relatori
correlatore Dott. Fogli, Stefano
relatore Prof.ssa Breschi, Maria Cristina
relatore Prof.ssa Breschi, Maria Cristina
Parole chiave
- RhoA/rho-kinase
- prospettive terapeutiche
Data inizio appello
14/10/2009
Consultabilità
Parziale
Data di rilascio
14/10/2049
Riassunto
In this study was investigated the function of the Rho/ROCK pathway in different pathologies as the asthmatic and cardiovascular diseases. This signal trasduction has a crucial role in the regulation of the actin polymerization.
Morever, we have identified common drugs that have a mechanism of action Rho\ROCK dependent.
Finally, we have analyzed preclinical and clinical studies that investigate new inhibitors of Rho\ROCK pathway. We think that these new compounds could have a future promising therapeutic applications and they could also show a sinergistic effects in association with the classic therapeutic approach.
Morever, we have identified common drugs that have a mechanism of action Rho\ROCK dependent.
Finally, we have analyzed preclinical and clinical studies that investigate new inhibitors of Rho\ROCK pathway. We think that these new compounds could have a future promising therapeutic applications and they could also show a sinergistic effects in association with the classic therapeutic approach.
File
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| FRONTESPIZIO.pdf | 28.14 Kb |
11 file non consultabili su richiesta dell’autore. |
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