ETD

Archivio digitale delle tesi discusse presso l'Università di Pisa

Tesi etd-06222009-105947


Tipo di tesi
Tesi di laurea specialistica
Autore
MAURIZII, LAURA
URN
etd-06222009-105947
Titolo
Sintesi e modellazione molecolare di inibitori della lattato deidrogenasi-A
Dipartimento
FARMACIA
Corso di studi
CHIMICA E TECNOLOGIA FARMACEUTICHE
Relatori
Relatore Prof. Minutolo, Filippo
Relatore Dott. Tuccinardi, Tiziano
Parole chiave
  • LDH
  • inibitori LDH-A
  • ipossia
  • metabolismo del glucosio
  • glicolisi
Data inizio appello
16/07/2009
Consultabilità
Parziale
Data di rilascio
16/07/2049
Riassunto
The hypoxia occurs when there is fast-growing solid tumor formation characterized by angiogenesis. The resistance of hypoxic cancer cells to radiation and anticancer drugs necessitates the search for new therapeutic approaches to affect the metabolism of these cells.
The attenuation of glycolysis in cancer cells, particularly through the inhibition of LDH-A may provide a new therapeutic strategy to counteract the development of cancer.
The objective of the first part of thesis was to synthesize new compounds that can inhibit the A isoform of lactate dehydrogenase. The second part focused on the computational study of some synthesized compounds; in particular I have performed docking calculations, minimization and molecular dynamics. I have also dealt with the development of a pharmacophore model, then used as a filter for the process of virtual screening to identify new potentially active molecules.
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