Tesi etd-03072008-191047 |
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Tipo di tesi
Tesi di dottorato di ricerca
Autore
SUARDI, MARCO ALESSANDRO
URN
etd-03072008-191047
Titolo
Purpose Tailoring of Bioactive-Biocompatible Polymers as Soluble Drug Carriers
and Hydrogels for Drug Delivery Systems
Settore scientifico disciplinare
CHIM/05
Corso di studi
BIOMATERIALI
Relatori
Relatore Prof. Ferruti, Paolo
Relatore Prof.ssa Ranucci, Elisabetta
Relatore Prof.ssa Ranucci, Elisabetta
Parole chiave
- polymer therapeutics
- poly(amidoamines)
- drug delivery sysstems
- biocompatible polymers
Data inizio appello
04/04/2008
Consultabilità
Completa
Riassunto
During the PhD course I have studied poly(amido amine)s based nanostructured systems, that can be considered as part of the huge field of the polymer therapeutics.
After a brief intrpduction about polymer therapeutics and a general review concerning poly(amidoamines), the work done during the PhD course is reported, divided in the following main chapters: Kinetic study of PAAs synthesis in organic solvents; Synthesis of new polymeric precursors of PAA-drug or PAA-protein conjugate by disulfide bond; Synthesis of nano-structured PAA-Cholesterol conjugates; Syntesys of cross linked polyplexes for applications in gene delivery; Glass surface functionalization for AFM imaging of lipid systems.
After a brief intrpduction about polymer therapeutics and a general review concerning poly(amidoamines), the work done during the PhD course is reported, divided in the following main chapters: Kinetic study of PAAs synthesis in organic solvents; Synthesis of new polymeric precursors of PAA-drug or PAA-protein conjugate by disulfide bond; Synthesis of nano-structured PAA-Cholesterol conjugates; Syntesys of cross linked polyplexes for applications in gene delivery; Glass surface functionalization for AFM imaging of lipid systems.
File
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| Suardi_PhDThesis.pdf | 4.81 Mb |
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