ETD

Archivio digitale delle tesi discusse presso l'Università di Pisa

Tesi etd-02232014-145508


Tipo di tesi
Tesi di dottorato di ricerca
Autore
CIAMPI, GIULIA
URN
etd-02232014-145508
Titolo
Epidermis-targeted drug-loaded nanoparticles for the treatment of psoriasis
Settore scientifico disciplinare
BIO/11
Corso di studi
SCIENZE BIOLOGICHE E MOLECOLARI
Relatori
tutor Chiellini, Federica
Parole chiave
  • polymers
  • nanoparticles
  • drug delivery
Data inizio appello
14/03/2014
Consultabilità
Completa
Riassunto
The research project constituting the body of the present thesis involves multidisciplinary skills. The focal point consists on the synthesis of novel polymeric biomaterials and realization of biocompatible polymeric nanoparticles and hydrogel designed for the controlled release of active principles. New dosage forms designed for controlled and targeted delivery of bioactive agents represent at present the best approach for maximization of the therapeutic efficacy, minimization of the adverse effects of drugs and administration of labile molecule otherwise degraded under conventional route.
The PhD research activity is focused on the following three main topics aimed at: (I) Synthesis and characterization of a novel amphiphilic copolymer with hydrophobic poly(ε-caprolactone) (PCL) branches and a hydrophilic poly(methacryloylglycylglycine) (p(MAGG)) chain; (II) Preparation and characterization of nanoparticles formulation based on chitosan (CS) and poly-γ-glutamic acid (γ-PGA) as vehicles for the topical sustained delivery of Methotrexate (MTX); (III) Development of injectable hydrogels based on chitosan (CS) and hyaluronic acid (HA) loaded with nanoparticles based on poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] (PHBHHx) for the sustained controlled delivery of dexamethasone (DEXA).
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