• pretrattamento ormonale
• Poor ovarian responders
• POF premature ovarian failure
• PMA procreazione medicalmente assistita
• ovociti
• IVF outcome
• gravidanza
• FSH
• estrogeni
• embrioni
• AMH
• progesterone

Premature ovarian failure(POF)is a disorder characterised by the cessation of ovarian function before the age of 40,with amenorrhoea,hypergonadotropinism and hypoestrogenism.It affects1-3%women of reproductive age.Several aetiologies have been postulated but most of the cases are idiopathic.Actually no treatment has been conclusively resulted in enhancement of fertility,thus the use of donor eggs is often the only possibility.Several studies showed, also,that FSH level for a good ovarian response could be10mUI/mL.Hormone replacement therapy in POF could correct the endocrine defect and may be a possibility to improve fertility.The aim of this study is to evaluate if a pre-treatment hormone therapy in patients with hypergonadotropic hypogonadism just prior to their ovarian hyperstimolation cycle can decrease FSH basal level, improve number and quality of retrieved oocytes and finally increase pregnancy rate.This is a retrospective study conduct in our Assisted Reproductive Centre of University of Pisa.